Experience with the use of bacteriophages in patients with neurogenic lower urinary tract dysfunction, complicated by recurrent lower urinary tract infection

Zaitsev A.V., Lysachev D.A., Stroganov R.V., Arefieva O.A., Dianov M.I., Bryanskikh E.P., Kovalenko А.А.

1) FGBOU VO “Russian University of Medicine”, Moscow, Russia; 2) N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia; 3) FGAU "Burdenko Neurosurgery Center" of the Ministry of Health of the Russia, Moscow, Russia; 4) GBU Scientific and Research Institute of the Healthcare and medical management of Moscow Health Department, Moscow, Russia; 5) FGBOU VO Kuban State Medical University of the Ministry of Health of Russia, Krasnodar, Russia; 6) S.P. Botkin’s State Clinical Hospital, Moscow, Russia

Clinical cases of three patients with neurogenic lower urinary tract dysfunction, complicated by chronic urinary tract infection are presented in the article. All patients underwent clean intermittent catheterization and, in order to prevent symptomatic lower urinary tract infections, received bacteriophage therapy with a clinically proven positive effect. During 3 months follow-up, there were no episodes of urinary tract infection. A change in the concentration of uropathogens and restoration of sensitivity to a number of antimicrobial drugs were observed. Although phage therapy in urology requires further clinical research, it provides an additional strategy to treat urinary tract infections considering an increase in antibiotic resistance.

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About the Authors

Corresponding author: A.V. Zaitsev – Ph.D., MD, professor at the Department of Urology of FGBOU VO “Russian University of Medicine”, Moscow, Russia; e-mail: zaitcevandrew@mail.ru

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