The effect of melatonin on male reproductive function (indicators of ejaculate)

Neymark A.I., Davydov A.V., Yakovlev A.V., Yershov A.V.

1) Altai State Medical University, Barnaul, Russia; 2) The First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation, Moscow, Russia; 3) The V.A. Negovsky Scientific Research Institute of General Intensive Care Medicine, Moscow, Russia

The review presents current scientific data on the role of melatonin in the male reproductive system normally and under the influence of various damaging factors. The role of oxidative stress as one of the leading pathophysiological mechanisms of the development of male reproductive system dysfunction is highlighted. It has been shown that up to 80% of infertile men have elevated levels of reactive oxygen species in their sperm. The results of studies devoted to the study of the effect of melatonin on ejaculate parameters under the influence of various damaging factors are presented. The safety and high cytoprotective activity of melatonin have been demonstrated during cryopreservation of spermatozoa, exposure to chemotherapeutic drugs, heat stress, radiation, and radiofrequency radiation. The use of melatonin in disorders of male reproductive function is a promising area, however, it requires careful study in clinical trials.

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About the Authors

Corresponding author: A.V. Yakovlev – Cand. Med. Sci. Assistant Professor at the Department of Urology and Andrology with a course in Advanced Medical Education, Altai State Medical University, Barnaul, Russia, e-mail: andryakovlev81@mail.ru

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