Assessment of the sensitivity of Eschericia coli to nitrofuran derivatives – an important issue in the context of growing antimicrobial resistance

Rafalskiy V.V., Tsapkova A.A., Mikhailova L.V.

Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation

Urinary tract infections (UTIs) are among the most common infectious diseases. Antimicrobial therapy is the main component of UTI therapy. Current recommendations suggest the use of nitrofuran derivatives as first-line drugs for the treatment of uncomplicated UTIs. This group of drugs has the following advantages: slow development of resistance and high activity against E. coli. However, for some nitrofurans, it is impossible to obtain data on the prevalence of resistant strains due to the absence of sensitivity interpretation criteria. This review is devoted to the study of correlation of sensitivity data between class I nitrofuran derivatives and the possibility of comparing the activity of nitrofurantoin and furazidine against E.coli.

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About the Authors

Corresponding author: V.V. Rafalskiy – Ph.D., MD, professor, Head of the Department of General and Clinical Pharmacologyy of Immanuel Kant Baltic Federal University, Director of the Clinical Trial Centre of Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation; e-mail: v.rafalskiy@mail.ru

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