Fosfomycin as antibiotic prophylaxis in men undergoing transrectal prostate biopsy: a systematic review of the literature

Bernikov A.N., Govorov A.V., Bagateliya Z.A.

1) FGBOU VO “Russian University of Medicine”, Moscow, Russia; 2) Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin, Moscow, Russia

Transrectal prostate biopsy remains the standard method for prostate cancer diagnosis, but it is associated with a high risk of infectious complications. In recent years, fosfomycin has been increasingly used as an alternative for antibiotic prophylaxis due to the increasing resistance of pathogens to fluoroquinolones, its good safety profile and ease of use. Results of several studies dedicated to the efficiency of fosfomycin are highlighted in this review. Fosfomycin demonstrates significant advantages as a drug for the prevention of infectious and inflammatory complications in patients after prostate biopsy, especially in case of increasing resistance to fluoroquinolones. Its efficacy, safety and ease of use make it an attractive choice and a reliable alternative in the context of increasing antibiotic resistance. Combination regimens with fluoroquinolones may be preferable for high-risk group.

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About the Authors

Corresponding author: A.N. Bernikov – Ph.D., associate professor at the Department of Urology of FGBOU VO “Russian University of Medicine”, urologist at the Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin, Moscow, Russia; e-mail: bernikov@mac.com

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