Comparative analysis of the results of immunohistochemical study of androgen receptor expression in the epithelial tissue of the prostate gland in patients with prostate hyperplasia with testosterone deficiency and normal testosterone levels

Ibishev Kh.S., Lemeshko S.I., Uzhakhov M.-H.M.

1) Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia; 2) GBU RO KDC «Health» in Rostov-on-Don, Russia

Introduction. Benign prostatic hyperplasia (BPH) is a disease characterized by the growth of the periurethral glandular zone of the prostate gland, leading to lower urinary tract obstruction and lower urinary tract symptoms (LUTS).
Objective. To conduct a comparative analysis of the results of an immunohistochemical study of androgen receptor expression in prostate epithelial tissue in patients with BPH with testosterone deficiency and normal testosterone levels.
Materials and methods. We analyzed the results of a morphological examination of resected prostate tissue from 188 men with BPH, divided into two groups: Group I – 71 patients with testosterone deficiency; Group II (control) – 117 patients with testosterone levels above 12.1 nmol/L.
Results. Immunohistochemical examination of prostate tissue samples from patients with Tc levels above reference values revealed a positive reaction for androgen receptors, detected both in the nuclei of glandular secretory cells and in their cytoplasm. In patients with testosterone deficiency, a weak positive reaction for androgen receptors was detected only in the nuclei of glandular secretory cells.
Conclusion. In patients with testosterone deficiency, androgen receptor expression in prostate epithelial tissue samples is reduced compared to patients with Tc levels within the reference range.

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About the Authors

Corresponding author: Kh.S. Ibishev – PhD in Medical Sciences, Professor of the Department of Urology and Human Reproductive Health (Course of Pediatric Urology-Andrology), Rostov State Medical University of the Ministry of Health of Russia, Rostov-on-Don, Russia; e-mail: ibishev22@mail.ru

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