Use of Longidaza® in chronic prostatitis: A systematic review and meta-analysis

Ibishev Kh.S.

Department of Urology and Human Reproductive Health (Course of Pediatric Urology-Andrology), Rostov State Medical University of the Ministry of Health of Russia, Rostov-on-Don, Russia

Introduction. Chronic bacterial prostatitis (CBP) is a disease with a multifaceted pathophysiological basis, including infectious, immunological, neurological, vascular, endocrinological, biochemical, and psychological factors, making it a multidisciplinary problem. One current treatment strategy is the use of the original drug Longidaza®, which has demonstrated efficacy in this disease, primarily due to its anti-inflammatory effect. A large number of original studies necessitate systematization of the results.
Objective. To conduct a comprehensive assessment of the clinical efficacy of Longidaza® (bovhyaluronidase azoximer) when included in the treatment plan for chronic prostatitis, based on data from controlled clinical trials.
Materials and Methods. A systematic review and meta-analysis were conducted according to the PRISMA protocol. Elibrary, PubMed, and Cyberleninka databases were used to search for articles. The search was conducted using a combination of keywords: chronic prostatitis and «Longidaza,» «Bovhyaluronidase azoximer,» among studies published no later than August 31, 2025.
Results. A search of scientific databases using the algorithms illustrated in Figure 1 yielded a total of 210 publications, of which 10 studies were then selected based on inclusion/exclusion criteria.
Conclusions. The results of the analysis suggest that adding Longidaza® to standard therapy for chronic prostatitis (antimicrobial and anti-inflammatory agents) significantly reduces clinical manifestations of the disease. Furthermore, the inclusion of Longidaza® in the treatment plan reduces inflammation in the prostate gland and improves maximum urinary flow rate, resulting in a significant reduction in the severity of chronic prostatitis.

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About the Authors

Corresponding author: Kh.S. Ibishev – PhD in Medical Sciences, Professor of the Department of Urology and Human Reproductive Health (Course of Pediatric Urology-Andrology), Rostov State Medical University of the Ministry of Health of Russia, Rostov-on-Don, Russia; e-mail: ibishev22@mail.ru

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