Modern view on the problem of diagnostics of renal angiomioadenomatous tumor

Osmanov Y.I., Kogan E.A., Gadzhieva Z.K., Radenska-Lopovok S.G., Prochenko D.D.

1) Institute of clinical morphology and digital pathology of FGAOU VO I.M. Sechenov First Moscow State Medical University, Moscow, Russia; 2) Department of analysis of personnel policy, educational programs and scientific research of the National Medical Research Center for «Urology». FGAOU VO I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Introduction. Angiomyoadenomatous tumor as a nosological entity is not included in the latest version of the International Histological Classification of Kidney Tumors (WHO, 2022) and is related to provisional entity. Currently, there is no consensus among researchers about the nosological affiliation of an angiomyoadenomatous tumor.
Aim. To comparatively analyze the histological, immunophenotypic, ultrastructural and molecular parameters of renal angiomyoadenomatous tumor and clear cell papillary renal cell tumor.
Materials and methods. The study was performed on surgical specimen from 5 and 10 patients with renal angiomyoadenomatous tumor and with clear cell papillary renal cell tumor, respectively. Immunohistochemical study was carried out on paraffin sections according to the standard protocol. Antibodies HMWCK, AE1/AE3, СК7, E-Cadherin, EMA, PAX8 and СА9 were chosen. To study tumor tissues on semi-thin and ultra-thin sections, an electron microscope Philips TECNAI 12 BioTwinD-265 was used. For in situ fluorescent diagnostic detection, defined centromere probes, LSI 13/21, LSI N25 /LSI ARSA, TelVysion telomeric probe and a two-color VHL/CEP3 probe
were used.
Results. Angiomyoadenomatous tumor is characterized by a three-phase structure. In contrast to clear cell papillary renal cell tumor, angiomyoadenomatous tumors show complete membranous expression of CA9.
Conclusion. Our results allow to state that angiomyoadenomatous tumor and clear cell papillary renal cell tumor are different neoplasms.

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About the Authors

Corresponding author: Y.I. Osmanov – Ph.D., MD, professor of Institute of Clinical Morphology and Digital Pathology of I.M. Sechenov First Moscow State Medical University, Moscow, Russia; e-mail: osmanovyouseef@yandex.ru